Insilico refer to the analysis which is carried out in computer environment rather then in laboratory .plant micro RNA are small non coding RNAs that have a length of 21 of 24 nucleotides which have role in growth and defense process . many plants mRNAs are evolutionary conserved from species to species . MiRNA precursor display high variability their mature sequence display expensive sequence complementarity to their target mRNA sequence MiRNA play very important role in plant post transcriptional gene regulation by target mRNA cleavage or repressing translation. MiRNA are involved in plant development , signals transduction ,proteins degradation, response to environment stress and pathogen invasion and regulate their Owen biogenesis . MiRNA regulate the expression of many important genes a majority of these genes are transcriptional factors . so hare we use homology method meaning searching for mRNA sequence which is involved in inti oxidant.The species that we selected is mentha canadensis .