FORMULATION AND EVALUATION OF MEBEVERINE HYDROCHLORIDE SUSTAINED RELEASE CAPSULES
Author(s):
Manasa.P, Suresh Kumar.P, Jagannath Patro.V, Sunitha.CH
Keywords:
Sustained release tablets, Matrix tablets, Mebeverine Hydrochloride, Ethyl cellulose, Micro Crystalline Cellulose, Hydroxy propyl methyl cellulose.
Abstract
The objective of present investigation is to develop and evaluate development and evaluation of sustained release matrix tablets of Mebeverine hydrochloride to achieve sustained drug release with reduced frequency of drug administration, reduced side effects and patient compliance and to prolong the drug release in GIT and consequently into the plasma. Sustained release matrix tablets of Mebeverine hydrochloride were prepared by using polymers like hpmc k100, ethyl cellulose, micro crystalline cellulose, talc, magnesium stearate, guar gum and starch. Mebeverine is an antispasmodic agent which exerts direct action on the GIT smooth muscle. Rapidly absorbed from the GI tract (oral); peak plasma concentrations within 1-3 hr. Mebeverine hydrochloride sustained release matrix tablets were prepared by direct compression method. The powder blend was subjected for pre-compressional parameters such as bulk density and tapped density, angle of repose, compressibility index and Hausner’s ratio. The prepared tablets are evaluated to post-compressional parameters such as hardness, friability, average weight, uniformity of weight and invitro dissolution studies. Drug compatibility with excipients was checked by FTIR studies. The values of precompressional parameters evaluated were within prescribed limits and indicated good free flowing property. The values of post-compressional parameters evaluated were within acceptable limits. The dissolution profiles of all the formulations were evaluated. Amongst all the formulations, the release profile of formula f6 gave optimum results. It was concluded that Mebeverine hydrochloride sustained release matrix tablets; f6 is successful formulation and can be manufactured with reproducible characteristics from batch to batch. The optimized formulation (F6) was compared to the marketed product and hence found to be superior over the marketed product.
Article Details
Unique Paper ID: 153501

Publication Volume & Issue: Volume 8, Issue 7

Page(s): 380 - 384
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