Microwave Green Synthesis of Pyrazolo-Pyrimidine Derivatives and Biological Profile Evaluation
Author(s):
Suresh HM, Suresha Kumara TH, Raghavendra H M
Keywords:
Pyrazolo-Pyrimidine Derivatives, Microwave, 1,3, di-ketones, Hydrazine hydrates, Urea/thiourea, Benzaldehyde, Anti- bacterial, Anti-fungal activity.
Abstract
Pyrazolo-Pyrimidine structural moieties are the crucial elements for the preparation of aimed drugs which are biologically various numerous importance features indirectly encourages budding scientists to synthesis other pyrazoles-pyrimidine derivatives with similar behaviour but a better medicinal action including antimicrobial, anti-tumour, anti-inflammatory applications. Nitrogen containing heterocyclic cyclic synthetic organic researchers have focused towards green methods of synthesis by avoiding hazardous reaction steps which depend on organic solvents by the replacement of eco-friendly solvents. Microwave green synthesis creates a new stair in heterocyclic synthesis. Desire molecules were obtained the reaction between 1,3 di-ketones and hydrazine hydrates and urea/ thiourea with different aromatic aldehyde derivatives by using ethanol medium. New structures are being confirms with the support analytical techniques of elemental analysis(CHN) and spectral analytical data: FTIR, Proton(1H) and Carbon (13C) NMR spectra. All new moieties were screened for biological potential analysis: All the proposed products show moderate to excellent antimicrobial, activity against different gram +ve (st-aureus, bacillus-subtillis) and Gram –ve (E-coli) microbial strains. Meanwhile anti-fungal evaluation as regards fungus infection to man kinds and pets.
Article Details
Unique Paper ID: 155300

Publication Volume & Issue: Volume 9, Issue 1

Page(s): 546 - 551
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