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@article{185527,
        author = {Bhanupratap Vishwakarma and Sumeet Gupta and Sakshi Pandey and Priya Jha and Shizan Alam},
        title = {Modulating Bacterial Communication via Quorum Sensing Inhibitors: A Review of Therapeutic Potential},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {1753-1760},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185527},
        abstract = {Bacteria coordinate many of their pathogenic behaviors through a mechanism known as quorum sensing (QS), a cell-to-cell communication system that regulates virulence factor expression and biofilm development in response to population density. With the global rise of antimicrobial resistance (AMR), there is an urgent need for alternatives to conventional antibiotics that impose strong selective pressure and rapidly drive resistance. One promising strategy is the use of quorum sensing inhibitors (QSIs), which function by silencing bacterial communication rather than killing the cells directly. By targeting virulence pathways, QSIs reduce pathogenicity and biofilm resilience, offering a new antivirulence paradigm for infection management. Potential QSIs have been identified from diverse sources, including plant-derived compounds, microbial metabolites, synthetic small molecules, nanotechnology-based formulations, and even probiotic organisms. Despite their promise, several challenges remain, such as poor bioavailability, delivery hurdles in complex host environments, and the possibility of bacteria evolving QS resistance. Future work integrating QSIs with conventional therapies and advanced delivery systems could establish them as sustainable solutions against persistent infections.},
        keywords = {Quorum sensing, Quorum sensing inhibitors, Biofilms, Antivirulence therapy, Antimicrobial resistance, Natural compounds, Nanotechnology.},
        month = {October},
        }