A Comprehensive Review on Novel Oral Iron Syrup Formulations for the Effective Management of Iron Deficiency Anemia

  • Unique Paper ID: 187014
  • Volume: 12
  • Issue: 6
  • PageNo: 2674-2681
  • Abstract:
  • Iron Deficiency Anemia (IDA) remains one of the most prevalent nutritional disorders globally, disproportionately affecting women, children, and adolescents. Although conventional iron supplements such as ferrous sulfate and ferrous fumarate effectively restore iron levels, their use is frequently limited by gastrointestinal irritation, metallic aftertaste, and poor patient compliance. Recent advancements in oral iron syrup formulations have sought to overcome these challenges through innovations that enhance bioavailability, palatability, and gastrointestinal tolerance. Novel iron complexes such as ferric polymaltose, iron polysaccharide, and sucrosomial iron exhibit improved absorption and reduced adverse effects compared to traditional salts. The incorporation of bioenhancers like vitamin C, folic acid, and piperine further facilitates iron uptake and utilization. Natural sweetening and flavoring agents, including honey, fennel, and sugarcane syrup, not only mask unpleasant taste but also contribute to antioxidant and digestive benefits, rendering these syrups ideal for pediatric and geriatric patients. Moreover, emerging nanotechnology-based and herbal iron syrup formulations offer promising biocompatibility, enhanced stability, and hepatoprotective potential. This review presents an updated overview of recent developments in oral iron syrup formulations, emphasizing their technological innovations, pharmacological advantages, and future prospects in the effective management of Iron Deficiency Anemia.

Copyright & License

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{187014,
        author = {Miss. Nikita R. Tangade. and Mr. Vishnu K. Jadhav},
        title = {A Comprehensive Review on Novel Oral Iron Syrup Formulations for the Effective Management of Iron Deficiency Anemia},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {2674-2681},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187014},
        abstract = {Iron Deficiency Anemia (IDA) remains one of the most prevalent nutritional disorders globally, disproportionately affecting women, children, and adolescents. Although conventional iron supplements such as ferrous sulfate and ferrous fumarate effectively restore iron levels, their use is frequently limited by gastrointestinal irritation, metallic aftertaste, and poor patient compliance. Recent advancements in oral iron syrup formulations have sought to overcome these challenges through innovations that enhance bioavailability, palatability, and gastrointestinal tolerance. Novel iron complexes such as ferric polymaltose, iron polysaccharide, and sucrosomial iron exhibit improved absorption and reduced adverse effects compared to traditional salts. The incorporation of bioenhancers like vitamin C, folic acid, and piperine further facilitates iron uptake and utilization. Natural sweetening and flavoring agents, including honey, fennel, and sugarcane syrup, not only mask unpleasant taste but also contribute to antioxidant and digestive benefits, rendering these syrups ideal for pediatric and geriatric patients. Moreover, emerging nanotechnology-based and herbal iron syrup formulations offer promising biocompatibility, enhanced stability, and hepatoprotective potential. This review presents an updated overview of recent developments in oral iron syrup formulations, emphasizing their technological innovations, pharmacological advantages, and future prospects in the effective management of Iron Deficiency Anemia.},
        keywords = {Iron Deficiency Anemia; Oral Iron Syrup},
        month = {November},
        }

Related Articles