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@article{189349,
        author = {Rakesh Choudhary and hemant dhakne and sandhya dhurve and diksha dandge and yojana dhuri and sonal dhonnar},
        title = {Synthetic Strategies, Structural Insights, and Pharmacological Versatility of Chalcone-Derived Pyrazolines: A Review.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {5820-5842},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189349},
        abstract = {The alteration of flexible molecular structures is a key to the drug discovery in modern medicinal chemistry. The review gives in-depth analysis of pyrazoles derivatives obtained in the reaction of chalcone precursors, which point out there. relevance as a privileged group of heterocyclic compounds. As alpha, beta ketone intermediates, chalcones are subject to cyclization with several hydrozaine reagents to produce pyrazolines- a reaction that greatly increases structure rigidity, metabolic stability, and target selectivity. We discuss the development of synthetic procedures, starting with the long-established Claisen-Schmidt condensation to modern day green chemistry procedures, such as the microwave-assisted chemistry, and solvent-free approaches. Additionally, the review explains the complicated structural description of these compounds, which was done using sophisticated spectroscopic methods (FT-). 
Tautomeric behaviors and molecular connectivity to elucidate tautomeric behaviors and molecular connectivity, IR, NMR, FT-Raman) and computational DFT methods are used to elucidate tautomeric behaviors and molecular connectivity. The important element of this work is the critical one, Investigation of Structure-Activity Relationships (SAR), whereby the position of substituents can cause changes in biological activity. The review concludes by Appraising the vast pharmacological scope of these derivatives, namely, their potential to serve as powerful antimicrobial, anti-inflammatory, antioxidant and anticancer agents, chalcone-derived pyrazolines are promising agents to be used in, treating chronic therapeutic problems and multi-drug resistance.},
        keywords = {(Chalcones, Pyrazoline Derivatives, Heterocyclic Synthesis, Structure-Activity Relationship (SAR), Tautomerism, Pharmacological Potential, Green Chemistry, Drug Discovery).},
        month = {December},
        }