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@article{195222,
        author = {GURUPRASATH MANIKANNAN and HARIVIKRAM SUBRAMANI and GOWRI MANOHARI GUNASEKARAN and GOWSHIGAA SOMA SEKHAR and DR. DEEPSHIKA SARAVANAN},
        title = {Beyond the Gums: The Systemic Impact of Periodontal Therapy – A Comprehensive Literature Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {6955-6966},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195222},
        abstract = {Periodontitis is a chronic inflammatory disease initiated by dysbiotic biofilm accumulation and characterised by progressive destruction of the supporting structures of teeth. Increasing scientific evidence demonstrates that periodontitis contributes to systemic inflammatory burden and is associated with several systemic diseases, including diabetes mellitus, cardiovascular diseases, adverse pregnancy outcomes, rheumatoid arthritis, respiratory diseases, and neurodegenerative disorders. Periodontal therapy, particularly non-surgical mechanical debridement, has been proposed as a modifiable intervention capable of improving systemic health outcomes. This review critically examines the biological mechanisms underlying the periodontal-systemic link and evaluates current evidence regarding the impact of periodontal therapy on systemic disease markers and clinical outcomes. Strong evidence supports improved glycemic control following periodontal therapy in type 2 diabetes mellitus. Moderate evidence indicates beneficial effects on systemic inflammatory markers and endothelial function in cardiovascular disease. Evidence for pregnancy outcomes, rheumatoid arthritis, respiratory diseases, and neurodegenerative disorders remains emerging and heterogeneous. While definitive evidence for a reduction in hard systemic endpoints is limited, periodontal therapy represents an important component of comprehensive systemic disease management. Further large-scale randomised controlled trials are required to establish long-term systemic benefits.},
        keywords = {Periodontitis; Periodontal therapy; Systemic inflammation; Diabetes mellitus; cardiovascular disease; Periodontal medicine.},
        month = {March},
        }