Microwave-Assisted and Eco-Friendly Synthesis of Benzylidene Aniline Schiff’s Base & Its Anticancer Activity

  • Unique Paper ID: 195996
  • PageNo: 285-289
  • Abstract:
  • Cancer is a deadly disease many treatment strategies are available to treat cancer. Amongst the different chemical compounds, Schiff’s bases are considered ubiquitous owing to their ease of microwave-assisted and eco-friendly synthesis of benzylidene aniline and substituted benzylidene aniline. Schiff’s base has varied applications. In this work, we synthesized Schiff’s bases from substituted benzylidene anilines and characterized all the molecules by spectral analysis using IR, ¹H NMR, ¹³C NMR, and mass spectrometry. The compounds were further studied for their anti-cancer activity. These Schiff’s base ligands exhibit specific bioactivity and catalytic properties; some bioactive Schiff’s bases exhibit anticancer activity against various cell lines. The discovery of antitumor activity of Schiff’s base against various cell lines fascinates researchers to develop an anticancer drug without any side effects. Thus, the present study focuses on the anticancer activity of enamine linkage-containing compounds generally known as Schiff’s base.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{195996,
        author = {Syed Samiuddin Syed Riyazuddin and M.E Shelke},
        title = {Microwave-Assisted and Eco-Friendly Synthesis of Benzylidene Aniline Schiff’s Base & Its Anticancer Activity},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {no},
        pages = {285-289},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195996},
        abstract = {Cancer is a deadly disease many treatment strategies are available to treat cancer. Amongst the different chemical compounds, Schiff’s bases are considered ubiquitous owing to their ease of microwave-assisted and eco-friendly synthesis of benzylidene aniline and substituted benzylidene aniline. Schiff’s base has varied applications. In this work, we synthesized Schiff’s bases from substituted benzylidene anilines and characterized all the molecules by spectral analysis using IR, ¹H NMR, ¹³C NMR, and mass spectrometry. The compounds were further studied for their anti-cancer activity. These Schiff’s base ligands exhibit specific bioactivity and catalytic properties; some bioactive Schiff’s bases exhibit anticancer activity against various cell lines. The discovery of antitumor activity of Schiff’s base against various cell lines fascinates researchers to develop an anticancer drug without any side effects. Thus, the present study focuses on the anticancer activity of enamine linkage-containing compounds generally known as Schiff’s base.},
        keywords = {Microwave Synthesis, Schiff’s base, Spectral analysis, anticancer activity.},
        month = {March},
        }

Cite This Article

Riyazuddin, S. S. S., & Shelke, M. (2026). Microwave-Assisted and Eco-Friendly Synthesis of Benzylidene Aniline Schiff’s Base & Its Anticancer Activity. International Journal of Innovative Research in Technology (IJIRT), 12(no), 285–289.

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