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@article{206564,
        author = {Kothapalli Narendra and S Mohammed Salmaan and Sandhya Deepak Chavan and Krishna M and Bidisha Mahato and Kalpita Manik Patil},
        title = {Emerging Low Calorie Sweeteners in Diabetes Management: A comprehensive review of Rare Sugars, Polyols and Natural Compounds including Stevioside, Rebaudiosides, Mogrosides and Tagatose},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {2101-2114},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206564},
        abstract = {The increasing incidence of Type 2 Diabetes Mellitus in the world today makes the need to establish better glycemic management approaches to replace the traditional pharmacotherapy. Both functional and natural sweeteners have low glycemic properties and other complementary metabolic effects in a variety of ways. The features of the sweeteners investigated in this detailed review are the molecular characteristics that include the stereochemistry, glycosidic structure and hydrogen bonding patterns that define the physicochemical properties and receptor interactions. We discuss functions of formulations such as viscosity modulation, effects of osmotic pressure and water activity control which affect drug delivery and stability.The review is a critical analysis of the interactions of sweeteners with glucose regulation involving intestinal transporters (SGLT1, GLUT2), sweet taste receptor signaling (TAS1R2/TAS1R3), and gut microbiota pathways that mediate short-chain fatty acid formation and incretin secretion. Such sophisticated formulation techniques as microencapsulation, nanoencapsulation, stimuli-responsive hydrogel and co-delivery system are addressed because of their potential effect to increase bioavailability and therapeutic effectiveness. The translatability of sweetener-based interventions is evidenced by novel dosing systems (e.g., oromucosal systems), 3Dprinted formulations, and functional beverages. The role of biofunctional excipients of polymers, cyclodextrins and mucoadhesive systems in enhancing the solubility of drugs, stability and targeted action is investigated. Clinical data indicate that there are small curious but reproducible impacts of plant-based interventions on glycemic indicators with stevia and monk fruit showing glycemic impartiality. Some of the factors that are considered under safety include microbiome impacts, metabolomics profiling, and regulatory frameworks that focus on product standardization and quality control. Future trends emphasize the adoption of artificial intelligence in the area of sweetener design, customized nutrition strategies, and the increased pharma integration with the use of sophisticated detection methods.},
        keywords = {Sweeteners, Diabetes, Stereochemistry, glycemic index},
        month = {July},
        }