Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{210910,
        author = {Arti Modanwal and Anoop Kumar Singh},
        title = {Natural Pore Formers in a Glipizide Osmotic Pump: A QbD Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {6},
        pages = {2756-2764},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=210910},
        abstract = {Glipizide is a widely used second-generation sulfonylurea with a short half-life and poor water solubility, which makes it a sensible candidate for once-daily osmotic delivery. This review asks whether a controlled-porosity osmotic pump (CPOP) tablet of glipizide, built with a natural pore-forming system and developed by Quality by Design (QbD), is a reasonable idea to test. We read the abstracts of 35 papers on glipizide and on osmotic pumps. Glipizide has been released at near zero-order rates from elementary osmotic pumps, and two CPOP studies of glipizide used polyvinylpyrrolidone (PVP) or sorbitol as pore formers. Other osmotic tablets have been optimised with factorial, central composite and Box-Behnken designs, usually with release independent of pH and agitation. Natural materials appear in osmotic systems only as swelling or push agents. We found no study of a glipizide CPOP with a natural pore former, so the proposed system is an idea to be tested and not an established result. We outline a conceptual QbD pathway, candidate factors and in-vitro tests. The review is based on published abstracts and reports no experimental data.},
        keywords = {Glipizide; controlled-porosity osmotic pump; natural pore former; Quality by Design; zero-order release; Box-Behnken design},
        month = {November},
        }