ASSOCIATION OF HLA DRB1 ALLELES IN GENETIC PREDISPOSITION OF DAVANGERE POPULATION
Author(s):
VINAYAKUMAR J, JAYASIMHA V L, RAJESH B P, RANGASWAMY B E
ISSN:
2349-6002
Cite This Article:
ASSOCIATION OF HLA DRB1 ALLELES IN GENETIC PREDISPOSITION OF DAVANGERE POPULATIONInternational Journal of Innovative Research in Technology(www.ijirt.org) ,ISSN: 2349-6002 ,Volume 6 ,Issue 7 ,Page(s):49-52 ,November 2019 ,Available :IJIRT148830_PAPER.pdf
Keywords:
MHC, HLA, DRB1, T cells
Abstract
HLA region encodes several molecules that play key roles in the immune system. Strong association between the HLA region and autoimmune disease has been established for over fifty years. Association of components of the HLA class II encoded HLA-DRB1-DQA1-DQB1 haplotype has been detected with several auto immune diseases , including allergic asthma rheumatoid arthritis, type 1 diabetes and Graves’ disease. Molecules encoded by this region play a key role in exogenous antigen presentation to CD4+ T helper cells. These results provide further evidence of a possible role for bacterial, fungal and viral infection and CD8+ T cells in activation of immune responses. The advances being made in determining the primary associations within the HLA region and fungal allergy will not only increase our understanding of the mechanisms behind disease pathogenesis but may also aid in the development of novel therapeutic targets in the future.
Article Details
Unique Paper ID: 148830

Publication Volume & Issue: Volume 6, Issue 7

Page(s): 49 - 52
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Last Date 25 January 2020


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