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“IN-VITRO SPASMOLYTIC EFFECT OF ETHANOLIC EXTRACT OF CALOTROPIS GIGANTEA LEAVES ON ISOLATED CHICK ILEUM”- A RESEARCH ARTICLE

  • Unique Paper ID: 173350
  • Volume: 11
  • Issue: 9
  • PageNo: 2771-2777
  • Abstract:
  • The Calotropis gigantea (Asclepias gigantea), or giant milk weed, or crown flower is a species of Calotropis, which is native to Bangladesh, Indonesia, Sri Lanka, Malaysia, Thailand, India, China, Pakistan, Nepal, and Cambodia. It belongs to the family Apocynaceae. The plant's bark, roots, latex, leaves, and flowers are all recognized to have a variety of therapeutic uses. The study's objective was to use invitro experimental models to evaluate the ethanolic extract of Calotropis gigantea leaves spasmolytic activity in relation to atropine. The smooth muscle of the chicken ileum is extremely sensitive to pharmacological substances, especially those that interact with serotonergic, histaminergic and muscarinic receptors. It is a great model for researching the effects of agonists and antagonists because of its sensitivity. In this research, we use chicken ileum to evaluate the spasmolytic effect of ethanolic extract of calotropis gigantea leaves. The 100ug/ml of extract inhibited the actions of Acetylcholine due to presence of calotropin like cardiac glycoside.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 9
  • PageNo: 2771-2777

“IN-VITRO SPASMOLYTIC EFFECT OF ETHANOLIC EXTRACT OF CALOTROPIS GIGANTEA LEAVES ON ISOLATED CHICK ILEUM”- A RESEARCH ARTICLE

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