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A STUDY OF THE NEW IMIDAZO DESIGN AND SYNTHESIS [1, 2-A] THE ANTI-BACTERIAL ACTIVITY OF PYRIDINE DEVICATIVES

  • Unique Paper ID: 179337
  • Volume: 11
  • Issue: 12
  • PageNo: 6069-6072
  • Abstract:
  • Antibacterial activity of new imidazo[1,2-a] pyridine derivatives is the primary subject of this work, which also involves their design, synthesis, and assessment. The synthesis of a series of chemicals (9a-l) began with 4-methyl acetophenone and proceeded through many steps. We used Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR), and mass spectroscopy to explore the newly produced chemicals. Their ability to inhibit the growth of four common bacteria was examined via disc diffusion testing, which included Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis. Molecular docking experiments were conducted to provide insight into the interactions between ligands and receptors in the active site of bacterial DNA gyrase. Compound 9a showed the maximum inhibition against Bacillus subtilis, whereas compounds 9c, 9e, and 9g showed potential antibacterial activity, according to the data. Experimental findings were in agreement with the docking investigations, demonstrating that these compounds had antibacterial potential.
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  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 12
  • PageNo: 6069-6072

A STUDY OF THE NEW IMIDAZO DESIGN AND SYNTHESIS [1, 2-A] THE ANTI-BACTERIAL ACTIVITY OF PYRIDINE DEVICATIVES

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UGC Approved
Journal no 47859

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