Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{182384,
        author = {Mrs Roshini K V and Anzalna Nazreen and Janu K R and Tisby Baby Vadakkan and Fathima Sahala M A},
        title = {The Impact of CCSEA on Drug Discovery: A Regulatory Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {1402-1405},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182384},
        abstract = {The ethical use of animals in scientific research has become a subject of increasing concern, prompting regulatory bodies to implement stringent guidelines to safeguard animal welfare. In India, the Committee for the Control and Supervision of Experiments on Animals (CCSEA), under the authority of the Prevention of Cruelty to Animals Act, 1960, plays a pivotal role in overseeing and regulating animal experimentation. The guidelines and Standard Operating Procedures (SOP) established by CCSEA emphasize the use of the least sentient animals, the reduction of animal numbers, minimization of pain, and promotion of alternatives to animal use wherever possible. Institutional Animal Ethics Committees (IAECs) are mandated to ensure compliance with these rules and are authorized to approve small animal research proposals, with large animal protocols requiring direct CCSEA approval. This review explores the legal framework, ethical principles, and organizational mechanisms enforced by CCSEA, highlighting their impact on animal-based research in India, especially in educational and pharmaceutical institutions. A significant shift is observed in the use of non-animal models for academic training, supported by recent mandates from the Medical Council of India (MCI) and Pharmacy Council of India (PCI). Technological advancements like computer simulations, virtual labs, and imaging techniques have been adopted as effective alternatives, thereby reducing the dependency on live animal experimentation.},
        keywords = {CCSEA, Drug discovery, Ethics, IAEC, SOP,},
        month = {July},
        }