One Health Perspective on UTI-Causing E. coli: Linking Human, Animal, and Environmental Factors in Resistance Spread

  • Unique Paper ID: 183415
  • Volume: 12
  • Issue: 3
  • PageNo: 1421-1436
  • Abstract:
  • In a world invisibly stitched together by microbes, Escherichia coli, a familiar gut dweller, has become a stealthy global threat, fueling a silent pandemic of urinary tract infections (UTIs) resistant to once-reliable antibiotics. This paper unravels the complex web of antimicrobial resistance (AMR) through a One Health lens, where the worlds of humans, animals, and the environment intersect. From overprescribed pills in urban hospitals to antibiotic-laced feed on rural farms and genes floating freely in wastewater streams, we trace the pathways through which E. coli evolves, adapts, and spreads its arsenal of resistance. With genomic evidence linking hospital strains to poultry, rivers, and soil, the illusion of microbial boundaries dissolves, revealing a unified battlefield. We explore how social behavior, economic incentives, climate shifts, and policy gaps fuel this microbial insurgency, and how cutting-edge innovations, such as phage therapy and rapid diagnostics, offer hope. Drawing from global data, regional case studies, and cross-species genetic signatures, the study calls for more than surveillance; it demands solidarity. In this microbial era, where a single resistant strain can traverse continents undetected, the future of infection control lies in a united strategy. One planet. One pathogen. One Health.

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