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@article{184034,
        author = {Sufiyan Akhtar and Mohsin A Bagwan and Dr. Vivekanand A. Chatpalliwar and Jayhind L Bharti and Dr. Jagdish V Manwar and MR. BHUSHAN GUDALWAR},
        title = {In Silico Approach of Invistigation of Phytoconstituent from Azadirachta indica L, Caricapapaya, Curcuma longa L, Mangifera indica and Psidium guajava (guava) as Inhibition of CYP3A5 Enzyme through Molecular Docking for the Treatment of Malaria},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {3},
        pages = {4028-4049},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184034},
        abstract = {Malaria is one of the life threatening infectious diseases caused by protozoan parasite and spread by the bite of female anopheles mosquito and its species. A family of enzyme called Cytochrome P450s has the ability to break down certain drugs. Cytochrome P450 enzyme make the medicine either more or less active, depending upon the medicine. Cytochrome P450 3A5 (CYP3A5) is part of Cytochrome P450 family of protein in the body. It is responsible for breaking down medicines. It shows a trend for gametocytemia, parasitemia clearance rates. The structure of all selected chemical constituents of Azadirachta indica L. (Neem) (Nimbin, Gedunin, Salanin, Quercetin), Caricapapaya (Papain, Tocopherol), Curcuma longa L. (Tumerone, Zingeberene, Curcumine, Curlone) Mangifera indica (Mangiferin, Mangoleanone, Manglupenone, Mangostin), Psidium guajava (guava) (Guajavarin, Ascorbic acid, Citric acid, Limonene). The updated elucidated crystal structure of CYP3A5 was obtained from the RCSB Protein Data Bank (PDB) as entry 6MJM, 5VEU.},
        keywords = {Azadirachta indica L., Caricapapaya, Curcuma longa L., Mangifera indica, Psidium guajava (guava), PyRx.},
        month = {August},
        }