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@article{185057,
        author = {Subhabrata Das and Anupama Pattanyak and Aranya Ghosh and Amrita Panja and Sujata Maiti Choudhury},
        title = {Molecular Mechanisms and Nanotechnological Advancements Establishing Piperine as a Promising Anticancer Therapeutic},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {136-150},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185057},
        abstract = {Breast cancer is the most common malignancy in the world among women with high mortality rate and much influence on health economic burden. Emergence of chemoresistance to breast cancer requires the need to discover other anticancer agents, and piperine is a good option. Piperine is a good option in fighting cancer cells because it has several signaling pathways. It does this by stopping cell cycle and encouraging apoptosis, altering signaling protein expression, decreasing transcription factors and blocking tumor growth. Piperine along with other phytochemicals like paclitaxel, thymoquinone, hesperidin, bee venom, tamoxifen, mitoxantrone, piperlongumin and curcumin have shown a strong resistance in cancer to overcome drug resistance. The incorporation of piperile into the nanotechnology of carbon nanotube, PLG /PEG nanoparticle and liposome, greatly enhances the release and activity. This review summarizes the data on the chemical properties of piperine and its bioavailability, molecular targets in cancer, and the use of nanotechnological methods. Piperile has been demonstrated to have anticancer effects such as anti-proliferative, pro-apoptotic, anti-migratory, and anti-metastatic. It can also help regulate the immune response, prevent the self-renewal of cancer stem cells, act as a chemo-enhancer, cytotoxic agent and an anti-},
        keywords = {Piperine, Breast cancer, Apoptosis, Cell cycle arrest, Nanoparticles},
        month = {September},
        }