Organoid Intelligence: A New Frontier In Biological Computing

  • Unique Paper ID: 186206
  • Volume: 12
  • Issue: 6
  • PageNo: 610-615
  • Abstract:
  • Organoid Intelligence (OI) is an emerging interdisciplinary field that seeks to harness the computational capabilities of brain organoids—three-dimensional, lab-grown neural tissues derived from stem cells—for biocomputing applications. This project explores the foundational concepts, methodologies, and potential of OI as a novel paradigm for computing, distinct from traditional silicon-based architectures. By integrating advances in stem cell biology, neuroscience, microelectrode arrays, and machine learning, OI systems aim to emulate cognitive functions such as learning, memory, and adaptive behavior. The report outlines the process of cultivating brain organoids, interfacing them with bioelectronic devices, and training them through environmental feedback. Ethical considerations, technical challenges, and future directions—such as hybrid bio-digital systems and neuromorphic integration—are also discussed. This project underscores the transformative potential of OI to revolutionize computing, neurological research, and our understanding of intelligence itself.

Copyright & License

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{186206,
        author = {Prof.Salunkhe Shrikant D. and Ms.Samruddhi Rajendra Nikam and Ms.Sejal Prakash Pawar},
        title = {Organoid Intelligence: A New Frontier In Biological Computing},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {610-615},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186206},
        abstract = {Organoid Intelligence (OI) is an emerging interdisciplinary field that seeks to harness the computational capabilities of brain organoids—three-dimensional, lab-grown neural tissues derived from stem cells—for biocomputing applications. This project explores the foundational concepts, methodologies, and potential of OI as a novel paradigm for computing, distinct from traditional silicon-based architectures. By integrating advances in stem cell biology, neuroscience, microelectrode arrays, and machine learning, OI systems aim to emulate cognitive functions such as learning, memory, and adaptive behavior. The report outlines the process of cultivating brain organoids, interfacing them with bioelectronic devices, and training them through environmental feedback. Ethical considerations, technical challenges, and future directions—such as hybrid bio-digital systems and neuromorphic integration—are also discussed. This project underscores the transformative potential of OI to revolutionize computing, neurological research, and our understanding of intelligence itself.},
        keywords = {Brain Organoids, Biocomputing, Biohybrid Systems, Neuromorphic Computing, Artificial Intelligence (AI), Machine Learning (ML), Brain–Computer Interface (BCI), Neural Networks, Biotechnology, Stem Cell Technology, 3D Cell Cultures},
        month = {November},
        }

Cite This Article

  • ISSN: 2349-6002
  • Volume: 12
  • Issue: 6
  • PageNo: 610-615

Organoid Intelligence: A New Frontier In Biological Computing

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