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@article{188302,
        author = {Mishthi Prajapati and Sanat Mahendra Dhoke and Krupa Badava},
        title = {Metabolic Syndrome and Gynaecological Cancers: An Emerging Public Health Concern},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {1211-1220},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188302},
        abstract = {Metabolic syndrome (MetS), which is defined by central obesity, insulin resistance, dyslipidaemia, and hypertension, has become a significant global health concern. Its growing prevalence corresponds with the increasing incidence of non-communicable diseases and is heavily influenced by sedentary lifestyles, high-calorie diets, and obesity. Emerging research underscores a strong link between MetS and the onset and progression of gynaecological cancers, such as endometrial, ovarian, cervical, and breast cancers. The mechanisms that connect MetS to cancer development are complex and involve chronic low-grade inflammation, elevated insulin levels, insulin-like growth factor (IGF-1) signaling, oxidative stress, hormonal imbalances, and disturbances in adipokines. These biological changes encourage tumor formation, increase cell proliferation, prevent programmed cell death, and facilitate metastasis by fostering an environment conducive to cancer growth. Among the various gynaecological cancers, endometrial cancer exhibits the most significant epidemiological relationship with MetS, showing a two- to four-fold increased risk, particularly in postmenopausal women. Furthermore, obesity-related changes in estrogen metabolism and immune functions heighten the risk of cancer. 
Despite abundant evidence, MetS is still often overlooked and insufficiently managed in standard gynaecological oncology care. Implementing early screening and thorough management of MetS through lifestyle changes, nutritional interventions, weight loss, and medication may significantly lower the risk of gynaecological cancers and enhance long-term outcomes. Incorporating metabolic health into initiatives for cancer prevention and treatment is a crucial approach to reducing the global disease burden. This review provides an overview of the latest epidemiological findings, pathogenic mechanisms, and public health consequences, emphasizing the critical need for multidisciplinary prevention strategies and policy interventions.},
        keywords = {Metabolic syndrome; Gynaecological cancer; Obesity; Insulin resistance; Inflammation; Endometrial cancer; Public health.},
        month = {December},
        }