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@article{189102,
        author = {VIRAJ MADHUKAR KAKADE and Dr Amita Dongare and Prof.Swati S.Shindhe},
        title = {A BRIEF REVIEW ON: PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF PHYLLANTUS NIRURI (BHUMI AMLA)},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4611-4617},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189102},
        abstract = {Phyllanthus niruri, popularly known as Bhumi Amla or “Stone Breaker,” is a small annual herb belonging to the family Euphorbiaceae and is widely distributed in tropical and subtropical regions. It has been an integral component of traditional medicinal systems such as Ayurveda, Unani, and folk medicine for centuries. The plant is especially valued for its therapeutic role in liver-related disorders, kidney stone management, and various metabolic and infectious conditions. Owing to the growing interest in plant-based medicines and natural therapeutics, Phyllanthus niruri has emerged as an important subject of scientific investigation in recent years.
This review aims to present a comprehensive overview of the botanical features, phytochemical composition, and pharmacological properties of Phyllanthus niruri based on available scientific literature. Botanically, the plant is characterized by its small leaves, greenish flowers, and smooth capsule-type fruits. Phytochemical studies have revealed that Phyllanthus niruri is a rich source of diverse bioactive compounds, including lignans, flavonoids, alkaloids, tannins, saponins, terpenoids, and phenolic compounds. Among these constituents, lignans such as phyllanthin and hypophyllanthin have been extensively studied and are considered responsible for many of the plant’s therapeutic effects, particularly its hepatoprotective activity.
Pharmacological evaluations have demonstrated that Phyllanthus niruri exhibits a wide range of biological activities. Experimental studies confirm its effectiveness in protecting liver tissue against toxic damage, supporting its traditional use in the treatment of jaundice and hepatitis. The plant also shows significant anti-urolithiatic activity by inhibiting the formation and aggregation of kidney stones. In addition, its anti-diabetic, antioxidant, anti-inflammatory, antimicrobial, and antiviral properties further enhance its medicinal importance. These activities are largely attributed to its ability to neutralize free radicals, regulate metabolic pathways, and inhibit pathogenic microorganisms.
In conclusion, Phyllanthus niruri is a medicinal plant with immense therapeutic potential supported by both traditional usage and modern scientific evidence. However, further clinical trials, toxicity studies, and standardization of herbal formulations are essential to ensure its safe and effective application in modern medicine and pharmaceutical development.},
        keywords = {Phyllanthus niruri, Medicinal plants, Traditional medicine, Herbal medicine, Ethnopharmacology, Phytochemicals, Bioactive compounds, Antioxidant activity, Hepatoprotective effect, Antiviral activity},
        month = {December},
        }