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@article{189945,
        author = {Rutuja Nandu Zalte and Dr.Lokesh P. Kothari},
        title = {Mouth Dissolving Films for Patient-Centered Drug Delivery: An Innovative Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {7},
        pages = {8127-8135},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189945},
        abstract = {Mouth-dissolving films (MDFs) represent a modern and patient-friendly oral drug-delivery system designed to rapidly disintegrate in the oral cavity without the need for water. They offer significant advantages for paediatric, geriatric, and dysphagic patients while improving onset of action, bioavailability, and therapeutic compliance. This review provides a comprehensive overview of MDFs, including their mechanisms of action, classifications, and essential formulation components such as polymers, plasticizers, sweeteners, and active pharmaceutical ingredients. Various preparation methods—such as solvent casting, hot-melt extrusion, semisolid casting, solid dispersion, and rolling techniques—are discussed along with critical evaluation parameters like mechanical properties, disintegration time, dissolution behaviour, drug content, and stability. Although MDFs face formulation challenges such as limited drug-loading capacity, moisture sensitivity, and taste-masking requirements, they remain a promising platform for efficient and convenient drug delivery. This review highlights recent advancements, formulation strategies, and quality considerations, demonstrating the growing importance of MDFs in pharmaceutical innovation.},
        keywords = {First-pass metabolism, Mouth-dissolving films, Oral drug delivery, Rapid drug release.},
        month = {January},
        }