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@article{191284,
        author = {Manthan Chhagan Nimane and Rajeshree Muke and Pooja Pagare},
        title = {Anticancer Potential of Carica papaya Extracts in Colorectal Cancer: A Comprehensive Review of Mechanisms and Bioactive Compounds.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {5839-5842},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191284},
        abstract = {Colorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide, with increasing incidence in developing countries including India. Despite advancements in surgery, chemotherapy, radiotherapy, and targeted therapies,
treatment-associated toxicity, drug resistance, and high recurrence rates remain major challenges. These limitations have stimulated interest in plant-derived bioactive compounds as safer and complementary therapeutic agents. Carica papaya Linn., a widely consumed tropical plant, has gained significant attention due to its diverse pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, and anticancer activities. Various parts of the plant such as leaves, seeds, fruits, and peels contain biologically active compounds like flavonoids, phenolic acids, alkaloids, isothiocyanates, carotenoids, and vitamins.

This review comprehensively summarizes current scientific evidence on the anticancer potential of Carica papaya extracts in colorectal cancer. It highlights the phytochemical composition, molecular mechanisms involved in CRC inhibition, including apoptosis induction, cell cycle arrest, modulation of oxidative stress, and immune regulation. Additionally, limitations of current studies and future research perspectives are discussed to support the development of papaya-based therapeutics for colorectal cancer management.},
        keywords = {},
        month = {January},
        }