Solvation And Interaction Analysis of a Dithiobiureto-Substituted Pyridine in Ethanol–Water Media

  • Unique Paper ID: 195754
  • PageNo: 223-227
  • Abstract:
  • Heterocyclic pyridine-based compounds continue to attract considerable attention due to their significant role in pharmaceutical and medicinal chemistry. Pyridine, a six-membered heteroaromatic system, is widely present in biologically active natural products such as vitamins and alkaloids, making its derivatives valuable scaffolds for drug design. In the present investigation, viscometric and density measurements were carried out for 1-(5-t-butyl-2,4-dithiobiureto)-2-methyl-4-methoxy-3,5-dimethylpyridine in mixed solvent systems at a fixed concentration over a range of temperatures. The experimental data were employed to analyze solute–solvent interactions and the influence of solvent composition on molecular behavior. A decrease in relative viscosity with increasing temperature was observed, suggesting enhanced solvation and reduced intermolecular resistance. These findings provide meaningful insight into the physicochemical characteristics of pyridine derivatives and contribute to a better understanding of their solution behavior, which is essential for the rational development of effective pharmaceutical formulations.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{195754,
        author = {S.S. Padhen},
        title = {Solvation And Interaction Analysis of a Dithiobiureto-Substituted Pyridine in Ethanol–Water Media},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {no},
        pages = {223-227},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195754},
        abstract = {Heterocyclic pyridine-based compounds continue to attract considerable attention due to their significant role in pharmaceutical and medicinal chemistry. Pyridine, a six-membered heteroaromatic system, is widely present in biologically active natural products such as vitamins and alkaloids, making its derivatives valuable scaffolds for drug design. In the present investigation, viscometric and density measurements were carried out for 1-(5-t-butyl-2,4-dithiobiureto)-2-methyl-4-methoxy-3,5-dimethylpyridine in mixed solvent systems at a fixed concentration over a range of temperatures. The experimental data were employed to analyze solute–solvent interactions and the influence of solvent composition on molecular behavior. A decrease in relative viscosity with increasing temperature was observed, suggesting enhanced solvation and reduced intermolecular resistance. These findings provide meaningful insight into the physicochemical characteristics of pyridine derivatives and contribute to a better understanding of their solution behavior, which is essential for the rational development of effective pharmaceutical formulations.},
        keywords = {Pyridine derivatives, Physicochemical properties, Relative viscosity, Solute–solvent interactions, Temperature effect, Viscometric study},
        month = {March},
        }

Cite This Article

Padhen, S. (2026). Solvation And Interaction Analysis of a Dithiobiureto-Substituted Pyridine in Ethanol–Water Media. International Journal of Innovative Research in Technology (IJIRT), 12(no), 223–227.

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