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@article{200381,
        author = {Dr. Vaibhav Rameshrao Manjare},
        title = {Role of Vrana Shodhana and Vrana Ropana in Tissue Repair: A Review of Classical and Modern Concepts},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {12},
        pages = {990-997},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=200381},
        abstract = {The management of wounds has been a central focus of surgery since ancient times, and Ayurveda offers one of the most detailed and rational systems of wound care, particularly through the twin principles of Vrana Shodhana (wound purification) and Vrana Ropana (wound healing and tissue regeneration). These principles extend beyond local wound treatment to include systemic correction of Dosha imbalances, emphasizing a holistic approach. Modern biomedical science describes wound healing as a dynamic, multi-phase process involving hemostasis, inflammation, proliferation, and remodeling. Remarkably, the Ayurvedic concepts of Shodhana and Ropana correspond closely to these biological phases. This review critically examines classical teachings from the Sushruta Samhita, Charaka Samhita, and Ashtanga Hridaya and correlates them with contemporary understanding of tissue repair, including molecular mechanisms such as cytokine modulation, angiogenesis, and extracellular matrix remodeling. Key Shodhana dravyas (e.g., Nimba, Triphala, Haridra) exhibit antimicrobial, anti-inflammatory, and antioxidant actions, while Ropana agents (e.g., Jatyadi Taila, Madhu, Yashtimadhu) promote fibroblast proliferation, collagen synthesis, and re-epithelialization. The sequential logic of cleansing before healing aligns with modern wound bed preparation protocols. Clinical relevance is particularly strong for chronic non-healing wounds, diabetic foot ulcers, and infected wounds, where integration of these Ayurvedic principles can improve outcomes. Thus, Vrana Shodhana and Vrana Ropana offer a scientifically valid, stage-specific, and clinically applicable framework that complements modern wound care.},
        keywords = {Vrana, Vrana Shodhana, Vrana Ropana, wound healing, tissue repair, Ayurveda, inflammation, granulation},
        month = {May},
        }