SUB- ACUTE TOXICITY STUDY OF PFAS IN WISTAR RAT

  • Unique Paper ID: 201225
  • Volume: 12
  • Issue: 12
  • PageNo: 5464-5470
  • Abstract:
  • Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic environmental contaminants widely used in industrial and consumer products due to their hydrophobic and lipophobic properties. Their persistence in the environment and bioaccumulation potential has raised significant concerns regarding human and animal health. This review focuses on sub-acute toxicity studies of PFAS in Wistar rats, emphasizing oxidative stress parameters such as Superoxide Dismutase (SOD), Catalase experimental findings demonstrating altered antioxidant enzyme activity and increased lipid peroxidation in PFAS-exposed animals. The study highlights the importance of oxidative in assessing PFAS toxicity and suggests future directions for toxicological research and regulatory evaluation. [1–3]

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{201225,
        author = {KAJAL DWIVEDI and Ritik kushwaha and prashan katiyar and somnath},
        title = {SUB- ACUTE TOXICITY STUDY OF PFAS IN WISTAR RAT},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {12},
        pages = {5464-5470},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=201225},
        abstract = {Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic environmental contaminants widely used in industrial and consumer products due to their hydrophobic and lipophobic properties. Their persistence in the environment and bioaccumulation potential has raised significant concerns regarding human and animal health. This review focuses on sub-acute toxicity studies of PFAS in Wistar rats, emphasizing oxidative stress parameters such as Superoxide Dismutase (SOD), Catalase experimental findings demonstrating altered antioxidant enzyme activity and increased lipid peroxidation in PFAS-exposed animals. The study highlights the importance of oxidative in assessing PFAS toxicity and suggests future directions for toxicological research and regulatory evaluation. [1–3]},
        keywords = {PFAS, Wistar rats, oxidative stress, SOD, CAT, LPO, sub-acute toxicity (CAT), and Lipid Peroxidation (LPO). Sub-acute exposure, typically lasting 14–28 days, provides insight into early biochemical and physiological alterations before chronic damage occurs. PFAS exposure is strongly associated with the generation of reactive oxygen species (ROS), leading to oxidative imbalance, cellular damage, and organ toxicity. This review compiles},
        month = {May},
        }

Cite This Article

DWIVEDI, K., & kushwaha, R., & katiyar, P., & somnath, (2026). SUB- ACUTE TOXICITY STUDY OF PFAS IN WISTAR RAT. International Journal of Innovative Research in Technology (IJIRT), 12(12), 5464–5470.

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