ADVERSE DRUG REPORTING OF THE BENZODIAZEPINE GROUP

Mr. Indrajit Surya; Mr. Avinash Hamde; Ms. Syeda affifa; Mr. Manoj wavhale

ADVERSE DRUG REPORTING OF THE BENZODIAZEPINE GROUP

Authors: Mr. Indrajit Surya, Mr. Avinash Hamde, Ms. Syeda affifa, Mr. Manoj wavhale

Unique Paper ID: 178504
Volume: 11
Issue: 12
PageNo: 3920-3928

Keywords: Benzodiazepine.

Abstract:
Benzodiazepines are a widely prescribed class of psychoactive drugs used primarily for the treatment of anxiety, insomnia, seizures, and muscle spasms. Despite their clinical benefits, benzodiazepines are associated with a range of adverse drug reactions (ADRs), including drowsiness, cognitive impairment, dependence, withdrawal symptoms, and, in some cases, life-threatening respiratory depression—especially when used in combination with other central nervous system depressants. This study aims to evaluate and analyze the pattern, frequency, and severity of adverse drug reactions associated with benzodiazepines through a review of reported cases and pharmacovigilance data. Data were collected from hospital records, patient interviews, and established ADR reporting databases. The study also utilized standard tools such as the WHO-UMC causality assessment scale and the Naranjo algorithm to evaluate the likelihood that the observed ADRs were caused by benzodiazepines.The results indicate that a significant number of patients experienced mild to moderate ADRs, with sedation, dizziness, and dependence being the most commonly reported. Severe reactions, although less frequent, included respiratory depression and withdrawal seizures, particularly in elderly patients and those with long-term use. The findings underscore the need for increased awareness, better prescribing practices, and routine monitoring of benzodiazepine use. Enhancing the ADR reporting system can lead to early detection of drug-related risks and contribute to safer pharmacological practices.

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 12
PageNo: 3920-3928

ADVERSE DRUG REPORTING OF THE BENZODIAZEPINE GROUP

Available:https://ijirt.org/Article?manuscript=178504

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