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@article{184063,
        author = {k.Thanusha and M.G.Shree Mugi and S.A.Sivashini and M.Reema},
        title = {Pharmacoepigenetics: Unlocking Epigenome-Targeted Therapies for Next-Generation Drug Discovery},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {3},
        pages = {4050-4052},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184063},
        abstract = {Pharmacoepigenetics is an emerging field that explores how changes in the epigenome influence the way drugs act in the body and how this knowledge can be used for new therapy development. Unlike genetic mutations, which are permanent, epigenetic modifications such as DNA methylation, histone alteration, and regulation by non-coding RNAs can switch genes on or off without changing the DNA sequence itself. These changes are reversible, which makes them attractive targets for drug discovery. The ability to design medicines that can correct abnormal epigenetic patterns opens new doors for treating cancer, neurological disorders, and other chronic diseases. Recent advances in artificial intelligence, high-throughput screening, and CRISPR technologies have made it possible to identify and test epigenetic drug candidates more effectively. At the same time, challenges such as drug specificity, long-term safety, and ethical considerations remain important barriers that researchers must address. Even with these limitations, pharmacoepigenetics represents a powerful step toward personalized medicine, where treatments can be adapted to the unique biological profile of each patient. This paper discusses the scientific basis of pharmacoepigenetics, highlights current epidrug developments, and explores the opportunities and obstacles that will shape the next generation of drug discovery.},
        keywords = {Pharmacoepigenetics; Epigenetic drug discovery; DNA methylation; Histone modification; non-coding RNAs; Personalized medicine; Epidrugs},
        month = {August},
        }