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@article{188694,
        author = {Miss Reshma Raju Kale and Dr.Akshay M. Kasambe and Dr.Avinash S. Jiddewar and Mr Akib Nisar Khan and Miss Laxmi gajanan kawale},
        title = {OSMOTIC DRUG DELIVARY SYSTEM: SMART SOLUTION FOR SUSTAINED AND TARGETED THERAPY},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {2839-2851},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188694},
        abstract = {Osmotic drug delivery systems (ODDS) represent one of the most reliable and predictable controlled-release platforms, offering sustained and targeted drug delivery independent of gastrointestinal variables. These systems operate on osmotic pressure–driven mechanisms that ensure zero-order release, improved pharmacokinetic stability, and reduced dosing frequency Recent advancements, including nano-engineered membranes, asymmetric coating technologies, and colloidal osmotic cores, have significantly expanded ODDS applicability for poorly soluble and stability-sensitive drugs Push–Pull Osmotic Pumps (PPOP), Controlled-Porosity Osmotic Pumps (CPOP), SEOP, and enteric osmotic capsules provide versatile designs for extending release up to 24 hours while maintaining reproducibility and minimal dose dumping Additionally, innovations such as pH-responsive membranes for colon targeting and AI-based formulation optimization demonstrate the emergence of smart, next-generation osmotic systems Despite their advantages, limitations such as membrane sensitivity, manufacturing complexity, and solubility challenges still persist This review consolidates the principles, mechanisms, types, formulation strategies, recent advancements, applications, advantages, and limitations of ODDS based on research, highlighting their growing potential as a smart solution for sustained and targeted therapy.},
        keywords = {Osmotic drug delivery system; sustained release; push–pull osmotic pump; controlled porosity; asymmetric membrane; targeted delivery; zero-order release; nanomembrane; AI optimization.},
        month = {December},
        }