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@article{188996,
        author = {MR. Adinath Gajanan Bhone and MR. Parshwanath Subhashrao Dhoke and MISS. Shreya vilas Bhute and Mr. V S Suryavanshi},
        title = {Advances in Antihistamine Therapy: Pharmacology, Mechanisms, Clinical Applications and Future Prospects},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4350-4355},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188996},
        abstract = {Antihistamines represent one of the most important therapeutic classes in the management of allergic and inflammatory conditions. These drugs exert their activity primarily through inverse agonism at histamine receptors, predominantly H1, but additional anti-inflammatory, immunomodulatory and receptor-biased actions have expanded their scope. First-generation antihistamines are effective but associated with sedation and anticholinergic effects, whereas newer second- and third-generation agents provide enhanced selectivity, longer duration of action and improved safety profiles. Emerging research highlights their roles in cytokine modulation, mast cell stabilization and treatment of chronic urticaria unresponsive to standard therapy. This review provides an extensive overview of the chemistry, classification, mechanisms, pharmacokinetics, therapeutic applications, adverse reactions, comparative evaluation and future perspectives of antihistamine therapy.},
        keywords = {Antihistamines, Histamine receptors, Allergy, H1 blockers, Pharmacology, Review article.},
        month = {December},
        }