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@article{191679,
        author = {SHRUTI KOSHTA and DR REETESH YADAV and DR DEEPAK PATEL and DR PANKAJ TIWARI},
        title = {FORMULATIONANDEVALUATIONTOPICAL GEL CONTAINING LULICONAZOLE NANOPARTICLES},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {7539-7545},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191679},
        abstract = {New topical pharmaceutical options are critically needed for the treatment of fungal infections for prolonged therapeutic action. Luliconazole is a topical antifungal medicine for the treatment of fungal infection but bioavailability barriers of luliconazole approached to develop effective topical luliconazole solid lipid nanoparticles (SLN) gel formulation with prolonged therapeutic potential against tropical fungal infection.SLN of luliconazole was prepared by the solvent diffusion method using stearic acid & poloxamer 188. The preformulation studies were conducted for the authenticity of the leading moiety. Thereafter, the prepared SLN followed by gel formulations were subjected to physicochemical evaluation, in-vitro release profile of drug with kinetics studies. Thereafter, FTIR spectroscopy and scanning electron microscopy of the optimized formulation was done successfully. The results reveal that SLN F6 shows a significant entrapment efficacy with the highest entrapment of 92.13%±0.975. In particle size, size distribution and zeta potential analysis, SLN exhibit a mean particle diameter of ~344.3 nm, with unimodal size distribution, a polydispersity index of 0.168, intercept value 0.98 with 92% peak intensity and zeta potential ~18.8 mV.Further, G3 gel shows a higher entrapment efficacy with 91.39%±0.187 as compared to other formulation. The in-vitro drug release profile of the G3 gel with 1.5 % carbopol 934 w/v shows a sustained release profilewith79.57%±0.213ofthedrugreleaseevenafter24hrsofthetime. It is concluded that the Luliconazole loaded SLN based gel formulation containing carbopol 934 1.5%w/v is suitable for topical application and may show a much better result of anti-fungal activity.},
        keywords = {Solid lipid nano particles loaded Gel, Drug Content, pH of the Gel, In-vitro drug release study},
        month = {January},
        }