Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{192201,
        author = {CHANDANA VISHWAS and Dr. Reetesh yadav and Dr Deepak Patel and Dr Pankaj Tiwari and Mr depend Patle},
        title = {EVALUATION OF ANTI-RHEUMATOID ARTHRITIS ACTIVITY OF SELECTED NATURAL SEMI-SYNTHESIZED COMPOUNDS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {9},
        pages = {660-664},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=192201},
        abstract = {Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder characterized by synovial inflammation, progressive joint destruction, and systemic complications. Despite the availability of conventional and biological disease-modifying antirheumatic drugs, their long-term use is often associated with adverse effects and high costs, necessitating the search for safer and more effective alternatives. Natural compounds and their semi-synthetic derivatives have gained significant attention due to their enhanced pharmacological activity, improved bioavailability, and reduced toxicity.
The present study aims to evaluate the anti-rheumatoid arthritis activity of selected natural semi-synthesized compounds using appropriate in vitro and in vivo experimental models. The compounds were assessed for their anti-inflammatory, immunomodulatory, and anti-arthritic potential through parameters such as inhibition of pro-inflammatory mediators, reduction of paw edema, arthritic score, and histopathological examination of joint tissues. Standard anti-arthritic drugs were used for comparison.
The findings of the study demonstrate that the selected semi-synthesized compounds exhibit significant anti-rheumatoid arthritis activity, possibly by modulating inflammatory pathways and suppressing immune-mediated joint damage. These results suggest that natural semi-synthetic compounds may serve as promising candidates for the development of novel therapeutic agents in the management of rheumatoid arthritis.},
        keywords = {Rheumatoid arthritis; Natural compounds; Semi-synthesized derivatives; Anti-inflammatory activity; Immunomodulatory effect; Anti-arthritic agents},
        month = {February},
        }