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@article{204427,
        author = {Mr. Rishikesh Sidram Nadiwade and Dr. Kavaljit Satish Birajdar and Prof. Dasrao Ashok Patil and Nishigandha Sachin Chopade and Pooja Shivaji Shep and Niranjan Sidram Nadiwade},
        title = {A Review on the Anthelmintic Potential of Embelia ribes and Its Application in Herbal Medicated Lozenges},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {2096-2103},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204427},
        abstract = {Helminthiasis remains a major global public health challenge, particularly in tropical and subtropical regions, with millions affected by intestinal parasitic infections. The growing limitations of conventional anthelmintic agents, including drug resistance and adverse effects, necessitate the exploration of safe, effective, and patient-friendly alternatives. Embelia ribes Burm. F. (Xyridaceae), commonly known as Vidanga or false black pepper, is a well-documented medicinal plant in Ayurvedic medicine recognized for its potent anthelmintic properties attributed primarily to its bioactive compound embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone). This review comprehensively discusses the botanical characteristics, phytochemical constituents, pharmacological activities, and mechanisms of anthelmintic action of Embelia ribes. Furthermore, the review explores the formulation of herbal medicated hard candy lozenges incorporating ethanolic extract of Embelia ribes as a novel, convenient dosage form with improved patient compliance, particularly for pediatric and geriatric populations. Reformulation studies, physicochemical characterization, in-vitro dissolution profiles, drug-excipient compatibility (FTIR), and stability outcomes of the optimized lozenge formulation are critically reviewed. The optimized formulation (F5) demonstrated a drug release of 94.02% within 30 minutes with stable physicochemical parameters over a 3-month accelerated stability study. The review underscores the promising potential of Embelia ribes-based medicated lozenges as a herbal alternative for helminthiasis management and identifies areas warranting further in vivo and clinical validation.},
        keywords = {Anthelmintic activity, Embelia ribes, Embelin, Helminthiasis, Herbal medicated lozenges, Oral drug delivery, Vidanga.},
        month = {June},
        }