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@article{204445,
        author = {Samyaka Siddharth Khillare and Vinayak Mhaismale},
        title = {Deep Eutectic Solvents, Emerging Green Solvents for Pharmaceutical Applications},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {2273-2287},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204445},
        abstract = {Deep eutectic solvents (DES) have emerged as a novel and sustainable class of solvent systems offering tunable physicochemical properties, high solubilization capacity, and compatibility with green chemistry principles. Formed through specific interactions between hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs), DES exhibit melting points significantly lower than those of their individual components due to strong intermolecular hydrogen bonding interactions. Over the last two decades, DES have evolved from conceptual solvent alternatives to functional excipients in pharmaceutical formulation, drug delivery, and bioactive compound extraction. This review critically evaluates the historical development, classification, preparation strategies, physicochemical and thermodynamic behavior, molecular interaction mechanisms, analytical characterization techniques, and pharmaceutical applications of DES. Toxicological considerations and regulatory challenges associated with DES-based pharmaceutical systems are also discussed, along with future perspectives for their integration into sustainable drug development platforms.},
        keywords = {Deep eutectic solvents, Pharmaceutical formulation, Solubility enhancement, Green solvents, Drug delivery systems.},
        month = {June},
        }