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@article{206878,
        author = {Gurmeet Kaur and Anjali Dixit and Sharuti Mehta and Ayush Singh and Rishabh and Manju},
        title = {Microsponge Technology in the Era of Nanomedicine: Associating Conventional and Advanced Drug Delivery Systems},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {3055-3064},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206878},
        abstract = {Microsponge technology has arose as a erudite and multipurpose drug delivery podium accomplished of talking frequent boundaries related with conventional pharmaceutical dosage forms. Characterized by highly porous, cross-linked polymeric microspheres, microsponges facilitate controlled, site-specific, and sustained release of API while ornamental medicament stability, plummeting systemic toxicity, and refining patient compliance. Their exclusive absorbent manner allows well-organized encapsulation of miscellaneous medicinal agents, counting synthetic drugs, biologics, and phytopharmaceuticals, thus expansion their pertinence crossways manifold beneficial areas. Current review expansively reconnoitres the central ideologies, fabrication methodologies, physicochemical features, and modern progressions in microsponge-based drug delivery systems. Specific importance is positioned on traditional fabrication methods, counting quasi-emulsion solvent diffusion, suspension polymerization, and solvent evaporation techniques, alongside emerging technologies such as microfluidics, spray drying, supercritical fluid processing, electrohydrodynamic atomization, and three-dimensional printing. Additionally, the review unsympathetically scrutinizes the developing incorporation of microsponge technology with nanomedicine, importance the expansion of nano-embedded microsponges, hybrid nano–microsponge systems, stimuli-responsive carriers, and multifunctional nanocomposites intended to improve healing exactness and targeted drug delivery. Advanced microsponge systems including pH-responsive, thermo-responsive, enzyme-responsive, magnetic, floating, bioadhesive, colon-targeted, pulmonary, ocular, antimicrobial, and anticancer microsponges are deliberated with respect to their mechanistic attributes, therapeutic applications, and translational potential. Furthermore, contemporary innovations linking AI-assisted formulation optimization, Quality-by-Design strategies, and personalized medicine approaches are evaluated. Together, microsponge technology represents a critical bridge between unadventurous pharmaceutical systems and advanced nanotherapeutic stages, contribution substantial potential for the development of next-generation, patient-centric, and clinically translatable drug delivery systems},
        keywords = {Microsponge, Drug delivery, QbD, Nanomedicine, Microsphere},
        month = {July},
        }