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@article{186481,
        author = {Jitesh Gyanendra Dubey},
        title = {Molecular Docking Analysis and Evaluation of Anti-Malarial Properties of Cassia auriculata},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {12},
        number = {no},
        pages = {258-267},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186481},
        abstract = {Cassia auriculata (C. auriculata), a leguminous shrub native to Asia, has been traditionally used in Ayurveda to treat various ailments, including skin diseases, diabetes, and conjunctivitis. This study utilizes molecular docking simulations to investigate the binding interactions between compounds derived from C. auriculata and protein targets involved in malaria. The docking studies were conducted using Autodock Vina to evaluate the binding affinities of the compounds with specific proteins, including Plasmodium falciparum lactate dehydrogenase (PfLDH), purine nucleoside phosphorylase (PfPNP), and malarial M1 alanyl-aminopeptidase (PfA-M1). Visualization of ligand-protein interactions was performed using Biovia Discovery Studio, while toxicity assessments of the metabolites were carried out using ProTox III. Among the tested compounds, rutin and emodin showed significant binding affinities for PfLDH, with beta-sitosterol-beta-D-glucoside exhibiting the strongest interaction. For PfPNP, rutin demonstrated higher affinity compared to the standard drug mefloquine, and emodin surpassed bestatin in binding affinity for PfA-M1. Additionally, the toxicity analysis revealed that C. auriculata metabolites possess lower toxicity than conventional drugs, indicating their potential as safer therapeutic options. These findings highlight the promise of C. auriculata metabolites as potential antimalarial agents, warranting further drug discovery and development investigation.},
        keywords = {Plasmodium falciparum, Cassia auriculata, Senna auriculata, Anti-malaria, Rutin, Molecular docking.},
        month = {},
        }