Pharmacological and molecular docking study of Imidazole derivatives: A Review
Author(s):
Mayuri V. Bhosale, Nikhil N. Khot, Mayuri S. Bhadalekar, Abhishek Desai, Dr. N. B. Chougule, Omkar D. Kadam, Saurabh R. patil
Keywords:
Abstract
Molecular docking is frequently employed in contemporary drug design to comprehend drug receptor interaction. In order to anticipate the structure of the intermolecular complex formed between two or more molecules, a process known as molecular docking. This optimization problem describes the "best-fit" orientation of a ligand that binds to a particular protein of interest. In these studies, we learned about the docking analysis of numerous activities, including anticancer, antibacterial, anti-diabetic, anti-inflammatory, anticonvulsant, and antioxidant. The acquired results demonstrate that, for powerful chemicals, tests and docking results are consistent. For executing the molecular design or modification of these imidazole derivatives, as well as for comprehending the action mechanism, these computational studies can provide some relevant references. Considering the well obtained in vitro results, it was thought worthy to perform molecular docking studies, hence screening the compounds, inculcating both in silico and in vitro results.
Article Details
Unique Paper ID: 157827

Publication Volume & Issue: Volume 9, Issue 8

Page(s): 167 - 177
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