ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FAVIPIRAVIR BY UV SPECTROPHOTOMETRIC METHOD

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FAVIPIRAVIR BY UV SPECTROPHOTOMETRIC METHOD
Author(s):
KRISHNAPHANISRI PONNEKANTI, Addanki Anusha , MD Imamuddin, Nandi Srinitha, Pathlavath Vijay , Sandhiri Sravani
Keywords:

Abstract
Analytical chemistry is a branch of chemistry that deals with the separation, identification and determination of components in a sample. Aim of the present work was to develop a simple, rapid and economical method for estimation of Favipiravir by UV-Visible spectrophotometric method. Favipiravir is a modified pyrazine analogue that was initially approved for therapeutic use in resistant case of influenza. The linearity was studied by performing three independent analyte curves with six concentration levels ranging between (2-12μg/ml). The recovery results showed that the proposed method has an acceptable level of accuracy for Favipiravir which is from 50-150%. The %RSD values of precision was found to be < 2. LOD was found to be 0.0178 whereas LOQ was 0.054. The method was validated as per the guidelines laid by ICH. The results of validation test were found to be satisfactory and therefore this method can be applied successfully to analysed drug formulation.
Article Details
Unique Paper ID: 162308 Publication Volume & Issue: Volume 10, Issue 9 Page(s): 227 - 232
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