Ranjith Kumar Ambati, Dr Pabba Parameshwar
bilastine, gastroretentive, pharmacokinetic profile.
This study investigates the pharmacokinetic profile of bilastine-loaded gastroretentive floating tablets. Bilastine, an antihistamine, is utilized for its potential in managing allergic conditions. The formulation involves the development of gastroretentive tablets to enhance drug bioavailability and optimize therapeutic efficacy. The research encompasses the formulation of bilastine-loaded gastroretentive floating tablets and subsequent in vitro characterization. The pharmacokinetic evaluation is conducted through a well-designed study involving an appropriate animal model. Parameters such as maximum plasma concentration (Cmax), time to reach Cmax (Tmax), and area under the concentration-time curve (AUC) are analysed to assess the drug's absorption, distribution, and elimination. The results reveal crucial insights into the pharmacokinetic behaviour of bilastine when delivered through gastroretentive floating tablets. The discussion interprets these findings, drawing comparisons with existing literature and formulations. The study's implications for advancing drug delivery strategies and optimizing bilastine's therapeutic outcomes are explored.
Article Details
Unique Paper ID: 162475

Publication Volume & Issue: Volume 10, Issue 10

Page(s): 964 - 976
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