Heat exchangers that are more efficient, compact and less expensive, heat transfer enhancement has gained great momentum. For this purpose, two techniques have been identified: passive and active. Convective heat transfer can be enhanced passively by changing flow geometry. The symmetrical corrugated channel is one of several devices employed for enhancing the heat and mass transfer In this study, heat transfer rate for semi oval corrugated channel has been investigated through CFD. Computational Fluid Dynamics (CFD) simulations of heat transfer and friction factor analysis in a turbulent flow in semi-oval corrugated channels with Al2O3-water nanofluid is presented in this study. Simulations are carried out at Reynolds number range of 10000-30000, with nanoparticles volume fractions 6% and constant heat flux condition. The results for corrugated channels are examined and compared to those for straight and semi- circle channels. Results show that the Nusselt number increased with the increase of roughness of corrugated channel and Reynolds number.