Regulation of blood sugar levels is highly complex mechanism. Various hormones and secretions help in order to keep check on levels of glucose. Pancreas plays the major role in almost all of the mechanisms. Hormonal reverse countering regulations like Insulin and Glycogen based on feedback mechanism controls the glucose homeostasis. The mechanism of insulin and glycogen mediated response is vital to maintain glucose homeostasis. The Pancreatic secretions are very much prone to the abnormalities and disturbances. The irregularities in the pancreatic regulation mechanisms results in diseases associated with glucose regulation such as Dysglycemia and Diabetes. The pancreatic regulation mechanisms carried out in body are significant to carry out furthermore studies for remedies. The understanding of ongoing mechanisms associated with glucose homeostasis also enable us to target specific level for therapeutic purposes. Particular actions of drug and their help in regulating blood sugar level will be discussed further.