The antifungal activity of medicinal weed plant Tridex procumbens was studied against the fungal pathogen Helminthosporium sativum isolated from Luffa acutangula. Leaf of the weed plant was screened with three different solvents including aqueous and two organic solvents of ethanol and methanol. Three different concentrations of solvents including 50ml, 100ml, and 150ml were prepared of plant extracts to test against the fungal pathogen. Disc diffusion method was used to study the effect of the botanical plant extracts against the isolated fungal pathogen. All plant extracts showed positive results except ethanol 50ml with no zone of inhibition. However, methanol 100ml and ethanol 150ml showed the best antifungal activity against H. sativum with average colony diameter of 31.7 mm and 28.5 mm respectively. Majority of the plant extracts showed neutral to positive impact against the growth retardation of H. sativum. Plant extracts can potentially be used as an alternative to commercial fungicides and therefore less hazardous to crop plants and environment.