The Piper betle is one of the antioxidant rich plant. Antioxidants protect degenerative diseases like cancer, carcinogenesis, protein damages, and chronic diseases and reduced cardiac diseases. CCL4 induce the severe hepatic damages in the liver. The purpose of this study was to investigate the hepatoprotective activity of Piper betle leaf extract against the CCl4 induced hepatotoxic male albino rats. Live male wistar albino rats (150 to 200 gms) were divided into four groups (Group I- normal control, II- CCL4 treated, III- CCL4+ leaf extracts treated and IV- CCL4+Sylimarin treated), each group had 5 animals for using the experimental period of 28 days of experiment. Silymarin was used as a positive control. At the end of the experimental period, the rats from each group subjected to diethyl ether anesthesia and blood samples were collected and serum was separated. Serum samples were used to estimate the bilirubin, protein and cholesterol and enzyme assays like AST, ALT and ALP. The liver was excised from each group for the estimation of liver glycogen and histopathological studies. Considerably reduced the impairments of CCl4 induced (0.1ml/kg/day for 14 days) liver damages in administration with Piper betle leaf extract (400mg/kg/day orally for 28 days) treated rats. The histopathological study was showing the normal hepatic cords and absence of necrosis, lesser fatty infiltration. Further we like to infer that Piper betle may have the antioxidant properties and inhibited lipid peroxidation in CCl4 induced hepatic damages.