Phytochemical investigation and evaluation of Anti-inflammatory activity of Camellia sinensis (Green Tea) leaves in Experimental Animals

Phytochemical investigation and evaluation of Anti-inflammatory activity of Camellia sinensis (Green Tea) leaves in Experimental Animals
Author(s):
Nagma Khan, Dr. Hemant Swami, Pooja Gourav, Monesh Kushwah, Pooja Raj
Keywords:
Camellia sinensis; anti-inflammatory; Arachidonic acid; Standardization
Abstract
Present work to evaluate anti-inflammatory activity of Camellia sinensis (Green Tea). Pharmacological studies were carried out with methanol-water (1:1) extract of green tea (Camellia sinensis) leaves extract. Leaves extract was found to possess anti-inflammatory, analgesic and antipyretic activities at 1/10th of its LD50 dose of 40 mg/kg i.p. Phytochemical parameter also perform like extractive value, ash value, loss on drying etc. to check the standardization of plant extract. It was found that leaves extract inhibited the arachidonic acid-induced paw edema in rats which indicated that leaves extract produced the anti-inflammatory activity by inhibiting both the cyclooxygenase and lypooxygenase pathways of arachidonic acid metabolism. Leaves extract enhanced peritoneal cell count and the number of macrophages in normal mice. It is possible that the saponins present in leaves extract may be responsible for these activities of Green tea leaves extract.
Article Details
Unique Paper ID: 151936 Publication Volume & Issue: Volume 8, Issue 2 Page(s): 156 - 161
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