SYNTHESI AND ANTICANCER ACTIVITY OF SOME NOVEL-1H-BENZO [D] IMIDAZOL-1YL)PYRIDIN-2-YL)(1H-IMIDAZOL-1YL)METHANONES
Author(s):
Srikanth Lingala, Pasham Venkanna
Keywords:
Benzimidazoles, Picolinic acid, anticancer activity, Antimicrobial activity, Cisplatin.
Abstract
The chemistry of benzimidazoles and its derivatives has been studied for over a century due to their diverse biological activities. They possess antibacterial, antiviral, antihypertensive, anthelmintic and antiinflammatory pharmacological activities. Benzimidazoles formed by the fusion of Picolinic acid moiety, have been reported to be chemotherapeutically active. In view of various biological activities and its enormous importance of benzimidazoles, we have made an attempt to synthesize and characterize some new (4-(2-substituted-1H-benzo[d]imidazol-1-yl)pyridin-2-yl)(1H-imidazol-1-yl)methanone derivatives and evaluate them for anticancer activity. 2-(substituted)-1H-benzo[d]imidazoles were treated with (4-chloropyridin-2-yl)(1H-imidazol-1-yl)methanone in presence of potassium tert-butoxide and dry N,N-dimethylformamide to give (4-(2-substituted-1H-benzo[d]imidazol-1-yl)pyridin-2-yl)(1H-imidazol-1-yl)methanones. All the intermediates and final compounds were purified and their chemical structures have been confirmed by IR, 1H NMR and Mass spectral data. All the newly synthesized compounds were screened for their anticancer activity by MTT assay and analyzed statistically. Compounds showed considerable anticancer activity when compared with Cisplatin.
Article Details
Unique Paper ID: 152551

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 943 - 947
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