Anti-Diabetic & Antioxidant Studies of Helictere Isora Roots

Kushavrta Karhale; Renuka R. Deshpande; Nandkishor B. Bavage; Vidyasagar Gali; Shyamlila B. Bavage

Anti-Diabetic & Antioxidant Studies of Helictere Isora Roots

Authors: Kushavrta Karhale, Renuka R. Deshpande, Nandkishor B. Bavage, Vidyasagar Gali, Shyamlila B. Bavage

Unique Paper ID: 149554
Volume: 6
Issue: 12
PageNo: 752-757

Keywords: Antioxidant activity Helicteres isora (L.) isolated rat hemi-diaphragm model thiobarbituric acid reactive species

Abstract:
The present investigations evaluated the antioxidant and antidiabetic activity of Helicteres isora (L.) fruits belonging to the family Sterculiaceae. The hot water extract of Helicteres isora fruits was prepared and screened for its in vitro antioxidant activity using 1,1-diphenyl,2-picryl hydrazyl assay, ÃŸ-carotene-linoleate model and microsomal lipid peroxidation or thiobarbituric acid reactive species assays and the IC50 values were calculated. Antidiabetic effect was studied using the in vitro glucose uptake in the isolated rat hemi-diaphragm model. The hot water extract of Helicteres isora showed maximum activity with IC50 value 25.12Â±0.18 Î¼g/ml for 1,1-diphenyl,2-picryl hydrazyl assay method, and low activity with IC50 value 740.64Â±4.76 Î¼g/ml for microsomal lipid peroxidation assay. In the ÃŸ-carotene-linoleate model, the extract showed 45.63% antioxidant activity. The extract produce a significant (P<0.05) uptake of glucose by isolated rat hemi-diaphragm but less effective to that of the reference drug, metformin. The hot water extract of fruit of Helicteres isora exhibited significant antioxidant activity and moderate antidiabetic activity and merits further investigation in animal models and isolation of its active constituents.

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Cite This Article

ISSN: 2349-6002
Volume: 6
Issue: 12
PageNo: 752-757

Anti-Diabetic & Antioxidant Studies of Helictere Isora Roots

Available:https://ijirt.org/Article?manuscript=149554

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