Formulation and In Vitro Evaluation of Bioadhesive Tablets Using Hydrophilic Gum Blends
Author(s):
Shivakanya Kendre, Pandhare Jayashri, Shrikant More, Renuka R. Deshpande
Keywords:
Theophylline, Xanthun gum, Locust bean gum, Controlled release
Abstract
Controlled release matrix tablets of theophylline were designed with hydrophilic gum blends as a bioadhesive polymer. Combinations of natural hydrophilic polymers such as Xanthan gum and Locust bean gum were used in different concentrations to formulate bioadhesieve tablets. Tablets of theophylline were prepared by direct compression method and were subjected to in vitro bioadhesion strength and in vitro drug dissolution for 12h by using USP dissolution apparatus basket type at speed of 100rpm at a temperature of 37 ± 0.5°C using simulated gastric fluid (pH 1.2). The bioadhesive strength of the tablets was measured as force of detachment against porcine gastric mucosa. The in vitro release study as well as retention time of bioadhesive tablets on mucous membrane were investigated to develop a bioadhesive polymer based controlled release delivery system and to evaluate the performance of such delivery device. Combination of xanthan gum: locust bean gum (4:6) in concentration of 1:0.5 (drug: gum) showed significant bio-adhesive strength and were dissolved in the gastric fluid with maximum release of 96.95% in 12h. Increase in gums concentration increases the drug release profile as well as bio-adhesive strength of tablets.
Article Details
Unique Paper ID: 149651

Publication Volume & Issue: Volume 7, Issue 1

Page(s): 207 - 212
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