Impact of Statins on Drug-Tolerant Biofilm of Mycobacteria
Author(s):
Aparna gaur, K. J. Gohil
Keywords:
Mycobacterium tuberculosis; cholesterol; statins; biofilms
Abstract
Tuberculosis is one of the 10 leading reasons for death on the earth. Tuberculosis is an airborne bacterial contamination brought by M. tuberculosis which influences any aspect of the body and most normally the lungs. M. tuberculosis has waxy covering on its cell surface basically because of the presence of mycolic acid. As of late, a few mycobacterial species, including M. tuberculosis, have been found to shape drug-tolerant biofilms in vitro through hereditarily controlled mechanisms. Bacterial biofilms are serious worldwide wellbeing worry because of their capacities to tolerate antibiotics, host defence systems. M. tuberculosis needs cholesterol to taint and get by inside the host. Host-directed therapies are a moderately new and promising way to deal with treatment of tuberculosis. Statins are inhibitors of HMG-CoA reductase, a rate-limiting enzyme of the cholesterol biosynthesis pathway, which catalyzes transformation of HMG-CoA reductase into mevalonate and have pleiotropic impacts, including wide reach immunomodulatory, anti-inflammatory and antimicrobial effects. It has been accounted that cells treated with statins are more resistant to M. tuberculosis disease. The point of this review to assemble the accessible logical information on the biofim development by Mycobacteria tuberculosis and impact of statins on M. tuberculosis and biofilms of microorganisms.
Article Details
Unique Paper ID: 150390

Publication Volume & Issue: Volume 7, Issue 5

Page(s): 149 - 159
Article Preview & Download


Share This Article

Conference Alert

NCSST-2023

AICTE Sponsored National Conference on Smart Systems and Technologies

Last Date: 25th November 2023

SWEC- Management

LATEST INNOVATION’S AND FUTURE TRENDS IN MANAGEMENT

Last Date: 7th November 2023

Latest Publication

Go To Issue



Call For Paper

Volume 10 Issue 1

Last Date for paper submitting for March Issue is 25 June 2023

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews

Contact Details

Telephone:6351679790
Email: editor@ijirt.org
Website: ijirt.org

Policies

Important Links

Browse Rsearch papers