Methylenetetrahydrofolate reductase Gene Polymorphisms as a risk factor in Rheumatoid Arthritis patients from North Coastal Andhra Pradesh
Author(s):
UMA BHARATHI HARIKOTI, Lakshmi Kalpana Veerathu , Ramakrishnam Naidu Adapa, Papa Kusuma Bunga
Keywords:
Rheumatoid Arthritis, Methylenetetrahydrofolate reducatse, Gene Polymorphism, Polymerase Chain Reaction, Restriction Fragment Length Polymorphism, Statistical Package for the Social Sciences
Abstract
Rheumatoid Arthritis (RA) is a chronic, systemic inflammatory, autoimmune disorder of unknown epipathogenesis that can affect many tissues and organs but principally attacks synovial joints. RA affects approximately 0.5 to 1% of the population worldwide, with women 2 to 3 times as likely as men to develop the disease. The etiology of RA is not yet known and it is considered to be multifactorial. Genetic and environmental factors play an important role in development of RA. The methylenetetrahydrofolate reducatse (MTHFR) enzyme has several crucial cellular process and its deficiency can have many consequences of folate status. So the genetic defects in folate metabolizing MTHFR gene have potential to affect RA risk. The aim of the present study was to investigate the association of MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) gene polymorphisms in rheumatoid arthritis patients from North Coastal Andhra Pradesh. A total of 300 samples (150 RA patients and 150 controls) were included in the present study and genotyping was accomplished by using PCR - RFLP technique. The data was analyzed by SPSS 19 software. Chi square p values revels that MTHFR (C677T) and MTHFR (A1298C) polymorphisms does not shows association with RA. The odds ratio p values of the variants MTHFR (C677T) and MTHFR (A1298C) were statistically insignificant with RA. It was concluded from the present study that there was no significant association of MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) gene polymorphisms with RA.
Article Details
Unique Paper ID: 152412

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 330 - 335
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