Comparison Effect of Penetration Enhancer On Drug Delivery System
Author(s):
SANJESH KUMAR, Mansi Singh, Praveen Kumar Shakya, Savita savi
Keywords:
Propranolol Hydrochloride, Transdermal Patches, DMSO, Permeation Enhancer, Diffusion Cell.
Abstract
Propranolol hydrochloride is used for the treatment of hypertension the purpose of this research article to study the comparison effect of penetration enhancer on drug delivery system using the natural permeation enhancer by using two polymer HPMC & EC and glycerin as plasticizer. Transdermal patches were prepared by solvent evaporation techniques. Controlled releases polymer was used for the formulation of patches. For in vitro drug release study pretreated with cellophane membrane using Franz diffusion cell. From the acquired results, propranolol hydrochloride with permeation enhancer (glycerin) was also successfully synthesized. DMSO remained to be an effective enhancer with hydrophilic polymer, the drug release kinetics of all transdermal patches follows the zero order kinetics, although the mechanism of drug release for all formulations was non-fickian diffusion.
Article Details
Unique Paper ID: 152573

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 867 - 873
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