A GENERAL REVIEW ON HANTAVIRUSES
Author(s):
Gandi Uma Rani, M.MONALISA, B.TEJASRI
Keywords:
Hanta virus, hanta viridae family, HFRS, HPS
Abstract
Hantaviruses are enveloped negative single‐stranded RNA viruses belongs to Hantaviridae family, it was hosted by small rodents and entering into the human body through inhalation. Hanta virus also cause Hantavirus pulmonary syndrome (HPS) hemorrhagic fever with renal syndrome (HFRS) and it also known as Hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses and its mortality rate is 35%–40%. Virus infect more than 200 000 people annually all around the world. Mainly viruses impair the honor of endothelial barrier due to an immoderate the immune response that is proposed to be central in the pathogenesis and is a hallmark of hanta virus disease. Different diagnostic tools including polymerase chain reaction (PCR), focus reduction neutralization test (FRNT), enzyme‐linked immunosorbent assay (ELISA), immune blot assay (IBA), immune fluorescence assay (IFA). Now we must have the availability of therapeutic modalities is the major challenge to control this deadly virus why means still no FDA approved drug or vaccine is available for hanta virus. DNA‐based vaccines, anti viral agents, monoclonal and polyclonal antibodies are neutralized the viruses. So these techniques as the hope for the treatment of Hantavirus disease. This review has been to provide an overview of hanta viruses’ disease, its diagnostic tools, Patho physiology and the treatment approaches to control the Hantavirus infection.
Article Details
Unique Paper ID: 152808

Publication Volume & Issue: Volume 8, Issue 4

Page(s): 484 - 489
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